The Rio Macaco Branco is a river in the far western region of Santa Catarina state, Brazil, flowing approximately 62 kilometers before emptying into the Rio Uruguai near the city of Itapiranga. The river originates in the area between the cities of São Miguel do Oeste and Descanso, running generally southward as part of the broader Plata Basin drainage system. Its mouth sits at an elevation of approximately 171 meters above sea level.

The river is used for rafting, with rapids ranging from Class 1 to Class 3+, making it accessible to a wide range of participants including beginners. The organized rafting experience also incorporates a section of the Rio Uruguai and the Rio Guarita. A pendulum jump is included as part of the commercial rafting route, in addition to the rapids and flat-water floating sections.

Access to the river is via a municipal road leading to Linha Laranjeira, near the Área de Lazer Barra do Macaco, approximately 6.6 kilometers from the center of Itapiranga. The commercial operation, Macaco Branco Rafting, provides transport from its base to the put-in point and back from the take-out. Each participant is provided with a life vest, helmet, and paddle. The minimum age for participation is six years, and a minimum group size of five people is required. Swimming ability is not mandatory.

Participants are advised to bring water, sunscreen, insect repellent, a towel, closed-toe footwear, and a change of clothes. Comfortable clothing suitable for getting wet and muddy is recommended.