Moleside Creek is located within Lower Glenelg National Park in Victoria, where it meets the Glenelg River. The creek serves primarily as a put-in point for paddlers beginning the river section of the Great South West Walk. A small wooden landing at Moleside Creek provides a practical launch point for canoes and kayaks, and a Moleside Canoe Camp is situated nearby, offering an overnight base for those starting or ending a paddle here. Canoe hire is available through local operators, with at least one provider (Nelson Canoe Hire, based out of Nelson) delivering equipment directly to the site.

From Moleside Creek, paddlers enter the slow-flowing waters of the Glenelg River. The river corridor is lined with red gums, black wattles, and reed beds. The standard day paddle from Moleside Creek follows the Glenelg River downstream, with landings at Saunders Landing and Pritchards Landing providing rest stops along the way. The full run to Battersby's Camp covers approximately 20.5 kilometres. Wind conditions on the river can shift direction between reaches, alternating between headwinds and tailwinds depending on the bend.

The area around Moleside Creek itself features a small picnic area and a short spur trail leading to a waterfall on the creek. A bridge crosses the creek near the campsite. The broader Lower Glenelg National Park supports populations of Gang-gang Cockatoos and Red-tailed Black Cockatoos, which paddlers may encounter along the river corridor.