The Rio Cipó originates within the Serra do Cipó National Park in Minas Gerais, formed at the confluence of the Rio Bocaina (also called Rio Palmital) and the Rio Mascates. It flows along the border between the municipalities of Santana do Riacho and Jaboticatubas before eventually draining into the Rio das Velhas. The river is characterized by a mix of waterfalls, rapids, and calmer stretches, making it suitable for a range of paddling styles and experience levels.

Kayaking and stand-up paddleboarding are the most common paddle activities on the river. Guided canoeing trips are available through local operators such as Cipó Trails, with at least one route traveling upstream to the confluence of the Rio Bocaina and Rio Mascates — the precise point where the Rio Cipó begins. This section features crystal-clear water and relatively undisturbed surroundings.

The Cachoeira Grande, one of the most prominent features along the river, is formed by the Rio Cipó itself. It measures approximately 60 metres wide and 10 metres high and is easily accessible, including for children and those with limited physical fitness. The surrounding complex includes the Rapids of Xica, Tomé, and Lageado, as well as several natural springs. Rafting is also practiced on the river, particularly around the more dynamic rapid sections.

The river sits within the Serra do Cipó National Park, which is part of the Espinhaço Mountain Range and the Cerrado biome. The park covers approximately 337 square kilometers and is recognized for its biodiversity, including endemic species. Wildlife in the broader park area includes the maned wolf. The park also features quartzite cliffs and high-altitude grassland terrain surrounding the river corridor.

Local outfitters offer guided paddling experiences, and the region has accommodation options in partnership with tour operators. The combination of accessible waterfalls and more technical rapid sections means the river can accommodate both casual paddlers and those seeking more active whitewater experiences.