Lac Tasiguluk is located within Kuururjuaq National Park in northern Quebec, a remote wilderness area accessible only by air or water, with no road connections to the surrounding region. The nearest community is Kangiqsualujjuaq, approximately 30 km from the park's coastal boundary. Access to the lake typically involves charter bush planes or commercial flights to the Kangiqsualujjuaq airstrip, followed by either a boat transfer along the Koroc River estuary or a floatplane to designated landing sites within the park, including a site at the edge of Tasiguluk Lake itself. Pilots require prior authorization from park authorities before landing at these points.

The lake sits in the southern portion of the Torngat Mountain Foothills natural region and serves as the outlet for the upper Koroc River. Paddlers should be aware that the Koroc River's water levels depend primarily on precipitation after spring freshets, as there is no large lake in the drainage basin to regulate flow. Starting in mid-July, rocks may become significantly more apparent on the river's surface downstream from Lac Tasiguluk's outlet, increasing the difficulty of navigation in that section.

The landscape surrounding the lake reflects dramatic glacial history. A deep subglacial gorge approximately 5 km long cuts through the plateau to the southeast of the lake, and an immense moulin kame roughly 20 metres high stands at its southern tip. The former shoreline of a proglacial lake that once flooded the surrounding valleys remains visible on the mountain slopes as green paths contrasting with the otherwise largely bare terrain.

One communal hut is planned at Tasiguluk Lake as part of the park's infrastructure, designed to accommodate up to 12 people with heating, bunks, tables, and emergency supplies including radios and GPS coordinates. The park operates under a permit system and encourages leave-no-trace principles for wilderness camping in non-preservation zones. Given the park's extreme remoteness and the tidal ranges exceeding 8 metres along the Koroc River estuary approach route, thorough logistical planning well in advance is essential for any visit.