The Rivière George (George River) is a major northern canoe expedition route in northeastern Quebec, flowing approximately 550–600 km due north from its headwaters near the Labrador border to Ungava Bay, dropping from roughly 425 m elevation at Cabot Lake to tidewater at the Inuit village of Kangiqsualujjuaq. The river passes through boreal forest, open tundra, and increasingly mountainous terrain as it descends toward the bay. The watershed is protected as a territorial reserve for biodiversity purposes under Quebec provincial designation.

The standard access is by chartered float plane from Schefferville, Quebec, to a small lake near the outlet of Cabot Lake. Schefferville is reached via the Tshiuetin Rail Transportation service from Sept-Iles, which runs twice weekly with canoes accepted as cargo. From the Schefferville rail station, a transfer of roughly 6 km reaches the floatplane base on Squaw Lake. An alternative put-in uses the De Pas River from Schefferville, which joins the George just south of Indian House Lake. A more demanding approach follows the historical Hubbard expedition route, crossing the height of land from Labrador via Smallwood Reservoir and Adelaide Lake into the George's headwaters at Hubbard Lake. The take-out is at Kangiqsualujjuaq, where paddlers typically depart by air. The final 40 km of the river is subject to tidal influence, and parties must coordinate their approach to the village accordingly.

Depending on the route chosen, the trip typically takes 15–17 days with as few as 3 portages on the standard route or up to 10 on the Labrador approach. The river is wide with numerous runnable rapids and crystal clear water. The lower reaches are notable for the boreal forest thinning and giving way to treeless tundra, a characteristic reflected in the Naskapi name Mushuan Shipu, meaning "River without Trees." Helen Falls is a significant landmark, and the Pyramid Mountains are a notable feature along the route.

Prevailing winds are from the northwest and rain is frequent. Mosquitoes are present throughout the journey; black fly activity intensifies below Helen Falls. The George River caribou herd, once among the largest in the world, has experienced a dramatic population decline in recent years. Wolves may also be observed along the route. The trip is rated as suitable for experienced paddlers and is considered an advanced expedition.