The Río Paraná is the second longest river in South America at approximately 4,880 kilometers, running through Brazil, Paraguay, and Argentina before emptying into the Atlantic Ocean via the Río de la Plata. Within Argentina, it flows through several distinct regions that offer very different paddling experiences, from the jungle-fringed upper reaches near the Misiones province to the vast, island-laced delta near Buenos Aires.

In the upper section near Puerto Bemberg and Puerto Iguazú in Misiones province, the river borders Paraguay and flows through the Paranaense jungle. Paddlers here encounter dense riparian vegetation, caiman sunbathing along the banks, howler monkeys in the canopy, parrots, toucans, and over 500 bird species, 300 fish species, and 85 orchid species. The river depth in this stretch runs around 6–8 meters. Sit-on-top kayaks are commonly used, and guided excursions typically depart from the beach at lodges, paddling along the shoreline and into side canals. One established route runs from Puerto Bemberg to the mouth of the arroyo Urugua-í. Difficulty is rated low, and trips are adapted to different fitness levels. Recommended gear includes closed-toe shoes, long pants, a swimsuit, sunscreen, and insect repellent. Children under 6 are excluded from some organized excursions. Departures are subject to weather conditions.

Near Rosario in Santa Fe province, the river flows amid slopes and islands, with fine sand beaches and shifting vegetation. Guided kayak tours in this area include helmet and neoprene suit use, suggesting more dynamic water conditions than the delta section.

The Paraná Delta near Tigre, just north of Buenos Aires, is the most accessible paddling area for visitors to the capital. The delta is a continuously growing freshwater sedimentary formation, unusual among the world's great deltas. Paddlers navigate a network of rivers and streams among islands, passing stilted houses and observing aquatic birds. Water quality improves significantly with distance from Tigre town; guided tours typically shuttle paddlers well upriver before launching to ensure cleaner conditions. Half-day trips are common, though longer multi-day explorations are possible. The climate throughout the Argentine Paraná corridor is temperate and humid. A recommended stay of one to three days is suggested for the Rosario area.