The Río Anizacate is a roughly 43-kilometer river in the Provincia de Córdoba, Argentina, forming at the confluence of the Río De La Suela and Río San José on the eastern slopes of the Sierras Grandes. From its source at approximately 783 meters elevation, it descends to around 433 meters at its mouth, where it joins the Río Xanaes (also known as the Río Segundo) near the village of Despeñaderos. The river is part of the endorheic Mar Chiquita basin and carries an average flow of 4.83 cubic meters per second.

The river is non-navigable and not suited for boat travel. Paddlers considering this waterway should take this designation seriously before planning any trip. The river's character is that of a shallow, sandy-bottomed mountain stream with clear water, and it is heavily used as a family recreation area during the summer months, particularly along the approximately 7-kilometer stretch near the town of Anisacate. Multiple vehicle access points exist along this stretch, including approaches via Avenida Los Naranjos and Avenida Los Eucaliptos, and there are camping areas along the banks.

The river's fauna has been affected by human pressure, though several fish species are still present. The ruins of one of Córdoba province's earliest hydroelectric plants remain at the locality of Los Aromos, a historical feature along the river corridor. The summer season sees the heaviest recreational use of the river.