The Río Quilipo is formed by the confluence of two tributaries, the Río San Gregorio and the Río Pinto, and flows through the sierra landscape near San Marcos Sierras in the Punilla region of Córdoba province. The water is clear and warm, with a character that varies considerably along its course — shallow, calm sections suitable for children alternate with deeper pools (locally called piletones or pozones) appropriate for swimming and kayaking, as well as small cascades. The river runs over white quartz rocks and through native monte vegetation, giving it a distinctive visual character.

Access to the river is via an unpaved gravel road that begins near the Plaza Cacique Tulian in San Marcos Sierras, following Calle Sarmiento out of town. There are five main access points along this road: the Camping Municipal, located approximately 5 km from the town center; Tío Rico; Reserva Natural 3 Piletas (also known as Tres Piletas), which offers deeper water and some services; Vado de López; and Casa de Piedra, the most remote access point at roughly 12 km from town. Each access point has a distinct character, and local tourism recommendations suggest spending a minimum of a full afternoon at each one.

For paddlers, the deeper piletones near Tres Piletas are suitable for kayaking. Between access points, the route involves crossing the river on stones in some sections and pushing through dense, thorny vegetation in others. Anyone traveling between access points on foot should wear long sleeves, long pants, gaiters if available, and footwear appropriate for wading. Cell phone signal is essentially nonexistent along the river corridor, so carrying cash and extra water is advisable.

The river also holds carp and tararira (a native predatory fish), making it a destination for anglers as well as paddlers. Fires are only permitted in designated areas. The Reserva Natural 3 Piletas is rated the top attraction in San Marcos Sierras on Tripadvisor, with 105 reviews and a 4.2 rating. Early morning and late afternoon visits are recommended for the best light conditions along the river.