Río Tabaquillo flows through the valley of San Miguel de los Ríos in the Sierras Grandes de Córdoba, running from its source down to its confluence with Río San Miguel, where it joins to form Río Santa Rosa. The river is characterized by clear, transparent water moving at a gentle pace among rocks, forming pools of varying depths along its course.

The final stretch of the river, roughly 300 meters before the confluence with Río San Miguel, is one accessible area of interest. Reaching this section requires obtaining permission from a private cabin and camping complex situated approximately 650 meters past the bridge at San Miguel de los Ríos — the same bridge that crosses the Tabaquillo. The access road to the complex is unpaved gravel, and caution is advised; vehicles with four-wheel drive are recommended. An alternative approach is to walk approximately 600 meters from the bridge, following the river's current downstream.

The river runs through a landscape of mountains and forest in the Sierras Grandes, and the surrounding area is noted for its birdlife. The water is notably clear. Río Tabaquillo is also included within Córdoba's regulated sport fishing zones, specifically for fly fishing, which is a common activity on mountain rivers in this province that run between slopes at altitudes of roughly 1,000 to 2,000 meters above sea level.

Given the river's calm, rock-strewn character and the access constraints imposed by private landholdings along its lower reach, paddlers should confirm entry permissions before planning any trip to this section.