The Weasel River flows through Akshayuk Pass (formerly Pangnirtung Pass) within Auyuittuq National Park on Baffin Island, Nunavut. The river is accessed from Pangnirtung, where paddlers typically travel by motorboat to the end of Pangnirtung Fiord before entering the valley. The upper river, below Summit Lake, contains the most technically demanding whitewater, with rapids reaching Class IV and at least one section just below Summit Lake Shelter that has been described as unnavigable for all but the most skilled paddlers. The overall river has been characterized as Class V on its first descent, with the primary challenge being rock-strewn passages where the difficulty lies less in reading water and more in avoiding being swept into rocks. Water levels can significantly affect the character of individual rapids.

River crossings are a notable hazard throughout the valley. Some crossings run fast and waist-deep, while others involve extended wading through cold, braided channels. Paddlers and hikers alike are advised to have a strategy for changing footwear and clothing, or to use dry pants. The cold water temperatures throughout the season make immersion a serious concern.

The surrounding landscape is dramatic, with sheer cliffs, glacial terrain, and prominent features including Mount Odin, Thor Peak (which rises 1,500 metres from the valley floor), Schwartzenbach Falls, and Crater Lake. Glacial retreat has left significant evidence throughout the area. The valley also carries deep cultural significance as part of a traditional inland route used by Inuit people traveling by qajaq.

Access to the area is highly seasonal. Late April is typically the cutoff for snowmobile transport into the region, making travel in May or June difficult or impossible without hiking from Pangnirtung. July has been used as a starting point for expeditions. A trail runs along the west side of the Weasel River and is generally well-defined, while the east side trail is rougher and in places nonexistent.

Given the remote Arctic location, the technical difficulty of the whitewater, the cold water, and the logistical complexity of access, the Weasel River is suited only to highly experienced paddlers with appropriate wilderness and whitewater skills.