The Rivière de Puvirnituq is a 389–413 km wilderness river in Kativik, Nord-du-Québec, flowing generally southwest from its source at roughly 588–609 metres elevation to Hudson Bay at the village of Puvirnituq. Its watershed encompasses 28,500 square kilometres. The Inuktitut name translates roughly as "smells like rotten meat." The river follows a geological fault line across the arctic tundra of Nunavik and is considered an advanced wilderness expedition.

Two access options exist for the upper river. The primary approach begins at Pingualuit National Park of Quebec, reached by chartered Twin Otter from Kangiqsujuaq to the Manarsulik Camp airstrip. From the park, the route follows the Vachon River upstream to St. Germain Lake, then descends the St. Germain River to reach the Puvirnituq, crossing a 160-metre height-of-land portage between the two watersheds. An alternative start is from Raglan Mine, a fly-in nickel operation near the river's source at Lake Raglan, though this requires arranging mine access. The river terminates at the village of Puvirnituq on Hudson Bay.

The river is divided into an upper and lower section with markedly different characters. The Upper Puvirnituq features a canyon with walls approximately 400 feet high and, while containing many rapids, is considered calmer relative to the lower section. The Lower Puvirnituq is described by paddlers as significantly more powerful and demanding. Sanguamaaluk Canyon, whose Inuktitut name means "changing direction," is a major highlight of the upper section, containing several difficult rapids in sequence. Qarqaq Rapid requires a 190-metre portage on river left. Immediately following is Inaqunaittuq Rapid, described as rocky, long, and difficult, with exceptionally sticky rocks that make canoe-wrapping a serious hazard; negotiating either shore is problematic due to turbulence throughout. At kilometre 356, a campsite is located on river left.

Wildlife visible along the route includes falcons, wolves, and caribou. A free digital map bundle covering the entire route is available through Canot Kayak Québec via the Avenza Maps app, marking rapids, portages, campsites, and other points of interest. Given the remote arctic tundra setting and the technical demands of the river, this is a multi-week expedition suited only to experienced wilderness paddlers.