Muscatine Slough Access provides a trailhead parking lot for the 1. 5-mile Muscatine Slough Trail, a moderate-difficulty hiking path that descends from upland forest into the river valley and floodplain, ending at an observation deck overlooking Lake Odesa.

The access point is located north of the Port Louisa National Wildlife Refuge office on 120th Street and serves as a gateway for wildlife observation and photography, though portions of the trail close September 15 to December 31 for migrating waterfowl and may flood during high water periods.