The Bloukrans River flows through a deep kloof in the Tsitsikamma region of South Africa's Garden Route, located along the old R102 road accessible via the Bloukrans Pass. The river is perhaps best known to paddlers and floaters as a kloofing destination, characterized by deep pools, rocky shores, sandy banks, and dense riverine foliage. The water has been described as surprisingly warm for a shaded gorge environment. The riverbed and banks feature slippery rocks throughout, making sturdy footwear essential for anyone navigating the river on foot between pools.

Access to the river float section begins at the old bridge in the Bloukrans Pass. Participants typically meet at the De Vasselot campsite in Nature's Valley before driving up the Groot River and down the Bloukrans Pass to the put-in. There is no official route along the river, allowing travelers to choose either bank or the middle of the river, or any combination. The trip ends at the ocean.

Practical considerations include protecting electronics carefully, as water exposure is essentially unavoidable. Wetsuits are worn by some participants while others manage with shorts and a T-shirt. Dry bags or waterproof containers are strongly recommended for valuables. A walking stick is useful given the slippery rock surfaces throughout the gorge.

The Bloukrans River mouth also features as the major river crossing on day four of the Otter Trail, where tidal conditions dictate timing. The crossing at the river mouth involves slippery rocks and can be deep, and is planned around low tide. Spring tides and incoming tides significantly complicate this crossing, and SANParks provides an alternative escape route via the Bloukrans Bridge approximately 2 kilometres upstream for those unable to cross at the mouth.