Río El Durazno originates on the eastern slope of Cerro Champaquí at elevations above 2,500 meters above sea level and flows through the Valle de Calamuchita in the Sierras Grandes de los Comechingones, Córdoba province. The river passes through the small settlement of El Durazno, located approximately 8 kilometers south of Villa Yacanto de Calamuchita and 36 kilometers from Santa Rosa de Calamuchita. The river ultimately contributes its waters to Lago Cerro Pelado, along with the Río Grande.

The river's character is defined by spring-fed, cold, and crystal-clear water. Along its course it features cascades, small waterfalls, deep natural pools reaching six meters or more in depth, and calmer stretches with sandy beaches. A particularly notable section is Los Cajones, where the river runs through a confined rocky gorge forming deep natural pools. The surrounding environment includes native Andean forest with molle, tala, and espinillo trees, as well as pine forest. The area sits at approximately 926 meters above sea level at the vado (ford) point.

The river is an ecologically protected area. Fishing is permitted but strictly catch-and-release only, consistent with regulations throughout the Calamuchita sierra region. Camping is only allowed in designated sites. The area has limited cell phone coverage, and weather can be unpredictable. The river and its water courses are potentially dangerous, and appropriate caution is advised. Speed limits of 30 km/h apply on local roads.

Spring and summer are the best seasons to visit. The water is consistently cold, being spring-fed from high-altitude origins, which is a year-round characteristic rather than a seasonal one. Water quality is pure spring water.

For paddlers, the river's confined gorge sections, deep pools, and rocky character make it more suited to swimming and wading than extended flatwater paddling. The river does feed into Lago Cerro Pelado, which is a kayaking destination. Access to El Durazno by public transport requires a bus connection from Santa Rosa de Calamuchita; private vehicle via Ruta Provincial 5 is the more direct option. Accommodation options in the area include over twenty cabins, a boutique hotel, a hostel, and several campgrounds.