The Río Mina Clavero originates in the Pampa de Achala within the Sierras Grandes and descends steeply through a short, swift course into the Valle de Traslasierra in western Córdoba Province. The river's source is marked by the Cascada del Nacimiento, a 102-meter waterfall located at kilometer 27 of Ruta Provincial 34 (Camino de las Altas Cumbres), approximately 30 kilometers from the town of Mina Clavero and about 100 kilometers from Villa Carlos Paz. A parador at the trailhead provides parking, and a short hike of moderate difficulty — involving a significant number of steps — leads to a natural overlook of the falls. A small entrance fee is charged to access the trail.

The river's waters are cold, clear, and mineralized, having passed through various rock corridors on their descent from the highlands. As it flows through and around the town of Mina Clavero, the river offers roughly 14 miles of sandy beaches, rock formations, small waterfalls, and natural pools. Several named swimming and recreation areas are distributed along this stretch, including La Toma, a family-friendly spot; El Nido del Águila, where canyon walls up to 22 meters high enclose the river and form deep natural pools; La Residencia, located about 900 meters from the central bridge; and Los Elefantes and Los Cajones, both known for their quieter atmosphere.

The river eventually meets the Río Panaholma, whose waters arrive warmer from the Pampa de Achala, and the two combine to form the Río de Los Sauces. The town of Mina Clavero is served by buses from Córdoba city (142 kilometers via RP34), though reaching the river source trailhead specifically may require a taxi or arranged transport from town.

Kayaking is a popular summer activity on the rivers in the area. The river was recognized in 2019 by the New 7 Wonders Foundation as one of the seven natural wonders of Argentina, reflecting its regional significance as a natural and tourist resource.