Arroyo Perucho Verna is a small stream in the Departamento Colón of Entre Ríos Province, Argentina, draining into the Río Uruguay as part of the broader Cuenca del Plata watershed. The stream originates in the southwest of Villa Elisa and flows eastward approximately 29.78 kilometers before emptying into the Río Uruguay near the paraje known as La Calera, south of Pueblo Liebig. Its drainage basin covers roughly 195 square kilometers and passes through the jurisdictions of Villa Elisa, San José, and Pueblo Liebig along its course.

Ruta Nacional 14 crosses the arroyo, providing a potential reference point for access. The stream also passes through the area natural municipal Los Teros, near San José, which is a designated municipal natural reserve.

The entire watershed of Arroyo Perucho Verna has been declared a Área Natural Protegida under the category of Reserva de Usos Múltiples by the legislature of Entre Ríos Province. This protected status may carry regulations affecting access and use; paddlers planning a trip should consult with provincial and municipal authorities — including the Dirección de Áreas Naturales Protegidas of Entre Ríos and the municipal government of San José — to confirm any restrictions that apply to recreational paddling within the reserve.

Nearby waterways in the same region include Arroyo Espinillo, Arroyo Gualeyán, Arroyo García, and Arroyo Ayuí Grande, all within Entre Ríos Province.