The Río Gualeguaychú flows through Entre Ríos Province in northeastern Argentina, originating in the center-east of the province within the Colón Department and running southward until it empties into the Uruguay River near the city of Gualeguaychú. Its drainage basin covers approximately 6,693 square kilometres.

The river passes directly through the city of Gualeguaychú, where a costanera (riverside promenade) runs along the bank and provides easy access to the water. Kayaking is an established activity on the river, with local operators offering guided kayak tours as well as motorboat excursions. The Balneario Norte, situated on the riverbank, offers boat rental options and serves as one practical access point for those looking to get on the water. The river also borders several balnearios (beach resorts) where sandy beaches slope gently to the water's edge.

The city of Gualeguaychú is best known for its carnival, held on Saturdays during January and February, which draws large numbers of visitors and significantly increases activity along the waterfront during that period. Paddlers planning trips during carnival season should anticipate elevated boat traffic and crowded riverside facilities. Outside of that window, the waterfront area is considerably quieter.

Given the river's location in the subtropical Mesopotamia region of Argentina, summer months (December through February) bring warm conditions, while winter (June through August) is mild. The river's character near the city is relatively calm and accessible, making it suitable for recreational paddling.