Arroyo Yuquerí Grande is a 54.03 km watercourse in the Departamento Concordia, Entre Ríos Province, part of the río Uruguay drainage basin. It originates at approximately 56 meters elevation in the Cuchilla Grande hills, where two smaller streams converge, and flows in a generally southeast direction before emptying into the río Uruguay near the southern edge of the city of Concordia, at the site of that city's former port.

The arroyo's character changes noticeably along its length. In the upper reaches, the water is clear and cool, with sandy banks, exposed rock, and dense riparian forest. Pindó palms rise above the forest canopy in these sections, and the corridor retains a largely undisturbed natural character. The principal tributaries — arroyo Chajarí (21.54 km), arroyo Carpinchorí (19.05 km), and arroyo La Báez (16.31 km) — join along the middle and lower course, along with several smaller streams including arroyos Concordia, Cambá Paso, and Portero.

The lower section of the arroyo passes through the urban fringe of Concordia, where it separates several peripheral neighborhoods from the city proper. Water quality in this lower stretch has been a concern, with ongoing institutional monitoring and recovery projects underway. Ruta Nacional 14 crosses the arroyo, providing a potential reference point for access. The name Yuquerí derives from Guaraní and refers to a plant of the mimosa genus whose fruit resembles blackberry.

Paddlers considering this waterway should be aware of the contrast between the relatively pristine upper sections and the degraded water quality in the lower urban reach near Concordia.