The Río Blanco in Los Lagos Region, Chile has at least two well-documented runs within the region, both fed by glacial and volcanic sources and characterized by the vivid azure color typical of glacial meltwater. The run near Hornopirén is defined by smooth granite boulders and blue glacier meltwater, giving it a visually striking character distinct from neighboring rivers. Paddlers traveling to Hornopirén should note that the town is accessible only via ferry from Puerto Montt, followed by a drive through increasingly remote terrain. Access to the upper sections may require negotiating with local landowners, and having a four-wheel-drive vehicle is advisable given the road conditions in the area.

The Rio Blanco de Calbuco, located on the southwestern flank of Volcán Calbuco within the Reserva Nacional Llanquihue and above Lago Chapo, is a low-volume run first descended in January 2012. To reach it, travel east from Puerto Montt on the paved road toward the Puelche Ferry, turn left just before Puente Chamiza, and head north to the small town of Correntoso — the road transitions from pavement to gravel along this stretch. From Correntoso, follow signs toward Lago Chapo and Río Blanco for approximately 5.2 kilometers to a parking area near a pisicultura. From there, paddlers carry their boats along a boardwalk trail through forest containing Tepa, Alerce, and Cipress trees. After roughly ten minutes, the trail forks: the left branch leads to the base of a 30-meter waterfall, while the right climbs steps to the national park entrance. Continuing past the guardaparque station for another ten to fifteen minutes brings paddlers to a bridge over the river. A Puerto Varas-based canyoneering company, Pachamagua, also operates organized tours in the spring and summer months on this section.

A separate class III+ section of Río Blanco is used as part of guided kayak itineraries operating out of the Puerto Varas area, positioned as a step-up run between the Río Petrohue and the Futaleufú. The hanging glaciers and mountain scenery along the Hornopirén corridor are noted as particularly striking by paddlers who have run the river.