Vincent DiFilippo Nature Preserve offers a 54-acre natural resource area with a 2-mile stone walking trail featuring inner loop options, interpretive signs, and benches along the Conodoguinet Creek.

A boat ramp near the parking lot provides direct creek access for paddlers, and the preserve includes a parking area off Sample Bridge Road in Mechanicsburg. The site features meadows and wetlands habitat ideal for both hiking and water-based recreation.