Marcus Hook Creek is a tidal creek in Pennsylvania, USA, flowing into the Delaware River Estuary. Its upper tidal limit is at U.S. Route 13 in Marcus Hook Borough, defining the navigable head of tide for paddlers. The main stem of the creek is approximately 5.8 miles in length, draining a watershed of about 5.2 square miles. As a tidal estuary feature, paddling conditions are entirely governed by the Delaware River's tides, not by freshwater river flow. Paddlers must plan trips around the tidal cycle, as the current direction will reverse with the tide; launching near high tide can provide easier upstream access before the ebb. The creek flows in a southeasterly direction towards its confluence with the Delaware River.

Primary access for paddlers is at the Naamans Creek Bridge, which serves as a known put-in/take-out location. The creek is situated in a developed industrial and municipal area near Marcus Hook Borough. The surrounding landscape includes the watersheds of Naamans Creek and Stoney Creek. Given its urban estuary setting, paddlers should anticipate potential boat traffic, especially near the mouth where it meets the busy Delaware River shipping channel. Water quality in this industrialized corridor can be variable. The area is subject to standard Pennsylvania Fish and Boat Commission regulations for boating, and paddlers should be aware that specific fishing regulations, including seasonal closures and size limits for species like striped bass, are in effect for the tidal Delaware Estuary, which includes Marcus Hook Creek.