Cefani Mouth Holiday Resort is a coastal getaway situated between East London and the Wild Coast in the Eastern Cape province of South Africa, at the mouth of the Cefani River.

It lies within the Amathole region and caters to caravans, campers, and those seeking self-catering accommodation.

The resort offers a variety of lodging options, including 27 camping sites, 12 chalets, 11 bungalows, rondavels, and more secluded cottages overlooking the lagoon.

Its setting at the river mouth provides a private beach and lagoon environment, with the nearby Inkwenkwezi Private Game Reserve adding a wildlife dimension for guests. The area is also within easy reach of Areena Riverside Resort and the Great Kei River.