Arroyo Feliciano is a river in the Argentine province of Entre Ríos, in the Mesopotamia region. It originates at the Lomada del Mocoretá in the northeastern part of the province, east of San José de Feliciano, and flows generally west-southwest for 198 kilometres before emptying into the riacho Alcaraz, a distributary of the Paraná River, near Puerto Algarrobo. Its drainage basin covers 8,303 square kilometres.

Along its course, the river receives the waters of numerous tributaries, including the arroyos Víboras, Atencio, Quebrachos, Puerto, Estacas Este, Banderas, de las Achiras, del Yeso, Estacas, Chimango, Don Gonzalo, Las Palmitas, Grande, and Alcaraz. Most of these tributaries originate on the slopes of the cuchilla de Montiel. The river passes through or borders the departments of San José de Feliciano, La Paz, and Federal.

Several road crossings provide potential access points along the river's length. Ruta Nacional 12 crosses at Paso el Quebracho, and provincial routes 6, 5, 28, and 2 also cross the river at various points. Paso Medina, a bridge crossing near La Paz, is one noted access location along the river.

The river supports a notable fishery. Golden dorado are present in good numbers and have been taken on both bait and fly fishing setups. Other species in the river include boga, bagre (catfish), amarillo, and mojarra. The presence of dorado in particular makes the river of interest to anglers who may share the water with paddlers.