The Río Huequecura flows through the Alto Biobío area of Chile's Biobío Region, in the vicinity of Santa Bárbara and the locality of Lo Nieve. The river originates in the cordillera, and its waters are noted for changing color depending on conditions — a characteristic that distinguishes it from many other rivers in the region. The river passes through a canyon section that gives the paddling experience a distinct enclosed, natural character.

Kayaking and stand-up paddleboarding (SUP) are both practiced on the Huequecura. At least one operator, based at Cuncumén in Lo Nieve, offers SUP sessions with a two-hour duration, available daily from 7:00 AM to 7:00 PM, strictly by prior reservation. Access to the river at this location is controlled — visitors without a confirmed reservation are not permitted entry, a policy the operator states is intended to limit environmental impact and manage visitor flow responsibly. Kayak rentals are also available at the same general area. A separate guided kayak outing has been offered combining Lago Angostura del Biobío with the Río Huequecura, suggesting the river connects or is used in conjunction with nearby lake paddling.

The Rivers of Chile whitewater database records the Río Cato as an upper tributary of the Huequecura, and notes that the Huequecura itself enters the Río Biobío downstream of the Queuco confluence, placing it within the broader Alto Biobío drainage system. The Cato entry is categorized under Class 3 whitewater, which may give some indication of the river's general character in upper sections, though conditions on the main Huequecura accessible to general visitors appear suited to recreational kayaking and SUP.

Accommodation options along the river include cabins for two people and glamping tent areas, with camping reportedly in development at some sites. At least one operator notes direct vehicle access to the river. One comment from a visitor flagged that river access at one of the cabin sites can be hazardous for children and adults, suggesting paddlers should assess bank conditions carefully before entering or exiting the water.

The river runs through native forest, and operators emphasize the presence of wildlife in the canyon. The nearest town with services is Santa Bárbara, a short drive away.