Fishing Creek originates at the confluence of its East and West Branches in southern Sullivan County, just north of State Route 118 near Grassmere Park, at an elevation of approximately 920 feet. The creek flows southward for nearly 30 miles through Columbia County before joining the Susquehanna River near Bloomsburg and Rupert at an elevation of 456 feet. This coldwater tributary drains a 385-square-mile watershed characterized by forested headwaters, agricultural valleys, and small communities along its lower reaches.

The creek supports exceptional trout fishing, with naturally reproducing populations of brook, brown, and rainbow trout throughout its length. Pennsylvania Fish and Boat Commission stocks several sections, while wild trout thrive in the upper watershed protected by State Game Lands 13. The creek maintains cold water temperatures rarely exceeding 65°F, ideal for salmonids. Anglers target multiple life stages across seasons, with notable hatches including Blue Wing Olives, Sulphurs, Green Drakes, and various caddis species.

Paddling opportunities exist primarily from spring through early summer when water levels permit safe passage. The creek becomes navigable from the Benton area downstream to the Susquehanna confluence, offering approximately 15-20 miles of Class I water suitable for beginners with good river reading skills. At optimal flows (Bloomsburg gauge reading 2-3 feet), paddlers encounter gentle riffles, pool-riffle sequences, and occasional rocky sections requiring maneuvering. Low summer flows often expose rocks and create shallow conditions, while spring runoff can produce swift currents and strainers from woody debris.

Access points include Camp Lavigne Road north of Benton, several locations in Stillwater and the Forks area, Orangeville, Lightstreet near Kocher Park, and multiple sites approaching Bloomsburg. The historic Rupert Covered Bridge crosses near the mouth, one of several covered bridges in the watershed. Pennsylvania Route 487 parallels much of the creek's length, providing convenient access.

The watershed features northern hardwood forests, riparian hemlock groves, and agricultural bottomlands. Wildlife includes white-tailed deer, black bears, wild turkeys, and diverse bird populations including herons, kingfishers, and occasional bald eagles. The creek's name reflects its historical importance as a fishing resource for Native Americans and early European settlers.

Two small dams exist near Benton, requiring portages. The Mill Race Golf Course dam and Benton dam both present low-head hazards. Water quality remains generally excellent in the upper watershed, though agricultural runoff affects lower sections. Pennsylvania fishing regulations apply, with special regulations on certain stretches. The creek experiences episodic acidification during spring snowmelt, particularly affecting the East Branch headwaters.

Multi-day camping opportunities exist at established campgrounds including Grassmere Park and Indian Head Campground near the mouth, allowing extended exploration of this premier Pennsylvania coldwater fishery.