Lake Andes National Wildlife Refuge encompasses Lake Andes, offering paddlers a unique opportunity to explore this shallow prairie lake. The refuge carefully manages water levels to foster desired plant growth, which may affect paddling conditions throughout the year. Wildlife viewing is a highlight, with various bird species inhabiting the area. Paddlers should be aware that sensitive areas may be closed to the public to allow for habitat recovery.

Access to the lake is available through North Point Recreation Area, located on the shoreline. This area provides amenities including a boat ramp, marina, and fish cleaning station. Campsites and cabins are available for overnight stays. The recreation area is open year-round, though some facilities like showers and flush toilets may be closed from October 1 to April 30.

Safety considerations include potential wind conditions and shifting sandbars, which can make navigation challenging. Paddlers should wear life jackets at all times and be prepared for changing weather. The lake's proximity to the Missouri River means paddlers may encounter stronger currents near the river confluence.

The area holds historical significance, with Lewis and Clark having passed through in August 1804. They noted seeing their first prairie dogs in this region, which they called "barking squirrels". Paddlers may spot wildlife including various bird species and possibly prairie dogs along the shoreline.

Before planning a trip, contact the refuge office for current information on water levels, closures, and any specific paddling regulations. The refuge's focus on conservation means restrictions may be in place to protect sensitive habitats or wildlife.