The Kariega River flows through the Eastern Cape province of South Africa, running through the Kariega Game Reserve before reaching the sea near the coastal village of Kenton-on-Sea. The reserve sits roughly 80 minutes east of Port Elizabeth (Gqeberha), accessible via the N2 toward Grahamstown, then the R72 toward Kenton-on-Sea and Port Alfred. The river mouth is notable for a strong tidal pull, which is worth factoring into any paddling plans.

Paddling on the Kariega River is available to guests staying at the game reserve's lodges, particularly River Lodge, which sits on the banks of the adjacent Bushman's River and provides canoes and kayaks for guest use at any time. The river cruise operation runs a 14-kilometre route from the river mouth up to the Kariega jetty, giving a sense of the navigable length of the waterway. The reserve also encompasses the Bushman's River, and guests at River Lodge and Settlers Drift have access to boat cruises on that river as well, including trips through Kenton-on-Sea to the beach.

The river valley is characterized by dramatic rock faces, euphorbia-covered hillsides, and open water that supports a wide variety of birdlife. African fish eagles are regularly sighted, and kingfishers are frequently encountered along the banks. The reserve is home to Big Five wildlife, hippos, and numerous other species, meaning paddlers should be aware of their surroundings. No crocodiles are resident in the section of the river near River Lodge, though the broader reserve carries a high dangerous-animal risk rating.

Fish species present in the river include Cob, Grunter, Leery, Catfish, Zebra, Mullet, and Steenbrass. The reserve is malaria-free, which is a relevant health consideration for trip planning. Paddling is an included activity for guests at River Lodge, while canoeing excursions are also offered as part of the broader safari experience at other lodges. Access to the river for independent paddlers not staying at the reserve is not confirmed, so those planning a visit should confirm access arrangements directly with the reserve.