Arroyo Ramón originates in the sierra de Misiones, rising between the cities of Oberá and Campo Ramón in the Departamento de Oberá, and flows in a southeasterly direction before emptying into the río Uruguay upstream of the town of Panambí. Its principal tributary is the arroyo Carrillo Viejo. The arroyo is the largest watercourse flowing through the Campo Ramón municipality.

Under normal water levels, the arroyo is not particularly navigable due to its character and volume. However, after heavy rainfall the stream rises significantly and generates numerous rapids and drops throughout its course, transforming it into a more demanding and technically interesting run. Paddlers should be aware that conditions can change substantially depending on recent precipitation.

A kayak traverse covers approximately 20 km, with the put-in at Villa Bonita. This trip takes roughly 6 hours of paddling time, with a total outing of around 10 hours. The route includes rapids and drops, and is best undertaken when water levels are elevated following significant rain. A bridge is located near the mouth of the arroyo before it reaches the río Uruguay.

Near Campo Ramón, there is a waterfall known as Las Cascada. Camping with direct access to the arroyo is available at a family-run site called Los Hermanos, situated just off Ruta Provincial 103. This provides a practical base for paddlers exploring the upper sections of the stream. The surrounding landscape is characterized by the native subtropical vegetation typical of Misiones province.