Five Fathom Hole Harbour is a small craft harbour in New Brunswick managed by the Harbour Authority of Lorneville and Five Fathom Hole. It serves approximately eight commercial fishing vessels, with lobster as the primary species landed at the facility.

In 2013, landings at the harbour represented an estimated value of more than $500,000.

The harbour received federal investment to improve safety and working conditions for fishermen as part of a broader Government of Canada initiative supporting small craft harbours.

It sits near the Musquash Estuary, designated as New Brunswick's first federal Marine Protected Area in 2006 in recognition of its extensive salt marsh habitat and natural condition.