Van Ewijcksluis is a small village and access point situated along the Van Ewijcksvaart canal in the Anna Paulowna polder, in the Noord-Holland province of the Netherlands.

The settlement takes its name from the historic lock (sluis) built in 1846 and named after Daniël van Ewijck, the first royal governor of Noord-Holland, who championed the polder's reclamation. The lock once connected the polder directly to the Zuiderzee.

The village grew up around the lock as a community of polderworkers and fishermen, and once supported a smithy, a small shipyard, a bakery, and a café.

Today Van Ewijcksluis remains a quiet settlement of roughly 90 houses and houseboats, with a marina, a café-restaurant, and access to surrounding waters popular for fishing.

It serves as a starting point for walking routes within the Noord-Holland walking network, with the Amstelmeer and Waddenzee both close by.