The Otheensche Kreek is a creek system located in Zeeuws-Vlaanderen, in the province of Zeeland in the southwestern Netherlands. The mouth of the creek lies on the east side of Terneuzen, and approximately one kilometer inland it divides into two tributaries: a southern branch running toward Axel and an eastern branch running south through Zaamslag. A large portion of this creek system remains navigable by water, and paddlers can travel many kilometers inland without interruption along its branching channels.

The creek's geography reflects a remarkable geological and historical story. The surrounding area of more than 1,350 hectares was reclaimed from the sea in a single operation in 1650, when the creek was dammed to create the Zaamslagpolder. Because the entire creek system was closed off at once, sediment supply from the sea was cut off simultaneously, preserving the original tidal relief almost intact. This is why so many of the creeks in the area have remained waterable to this day.

Terneuzen is noted as a base for nature canoe trails that extend up the Otheense Kreek, making it a recognized paddling destination within the broader Zeeland region. The creek is also a popular fishing spot, with Northern Pike, Common Carp, Round goby, and European perch among the species recorded there. Anglers fish from both the bank and from paddle boards, so paddlers should expect to share the water with fishing activity.

The creek has been highlighted as a particularly worthwhile destination at sunset, when the sky over the water takes on shades of orange, pink, and red. The Geopark Schelde Delta includes the Otheense Kreek among its geosites, accessible via the Kraagdijk in Terneuzen, reflecting its significance as a landscape of preserved tidal creek morphology within the delta region. Nearby comparable waterways in Zeeland include the Axelse Kreek, Molenkreek, and Berriekreek, which may be of interest to paddlers looking to extend their time in the area.