The Tuxedni River is a remote, tidal river located within Lake Clark National Park and Preserve in southern Alaska. Accessing the river typically requires a floatplane charter, with pilots landing on gravel bars or suitable shorelines; there are no established road-accessible launch facilities. The river flows into Tuxedni Bay and Cook Inlet, and its tidal nature is a primary consideration for paddlers. The tides have a significant range, with a 6-meter (approximately 20-foot) difference between high and low water, and they run swiftly. Paddlers must plan trips around these powerful currents, often paddling upstream against a strengthening ebb tide. The water is cold year-round, with a noted temperature of 9 degrees Celsius (48 degrees Fahrenheit) in early autumn.

The paddling experience is defined by its extreme remoteness and wilderness character. The river provides views of high mountain peaks and the white mass of the Tuxedni Glacier on the far bank. A notable cultural site along the route is a rock shelter containing ancient paintings, located on low granite cliffs. The area is a significant habitat for wildlife, including belugas and various seabirds, and serves as important winter foraging grounds. Paddlers should be prepared for complete self-sufficiency, as there are no amenities. Hazards include strong tidal currents, cold water immersion risk, and the logistical challenge of arranging and coordinating air transport, which is highly weather-dependent. Decision-making in this remote setting requires a conservative and heightened awareness of surroundings.