Opequon Creek is a scenic waterway that flows through Virginia and West Virginia, serving as a tributary to the Potomac River. Originating in Frederick County, Virginia, the creek meanders northward for approximately 35 miles before joining the Potomac northeast of Martinsburg, West Virginia. The creek forms part of the border between these two states, making it a unique interstate paddling destination.

The Opequon Creek Water Trail offers paddlers a variety of experiences, from peaceful flatwater sections to gentle Class I-II rapids. The creek is generally suitable for beginners and intermediate paddlers, with several well-mapped sections providing options for trips of varying lengths. The upper section, from Brucetown Bridge in Virginia to Bauserman Farm in West Virginia, offers a 14.7-mile journey through rural landscapes. Further downstream, paddlers can enjoy shorter trips like the 7.5-mile stretch from Route 45 to Hoffman Road, or explore the final 6 miles before the creek's confluence with the Potomac.

Water levels are best for paddling in spring and early summer, with the Opequon Creek Martinsburg Gauge operated by USGS serving as a reliable resource for checking conditions. Fall can also provide pleasant paddling opportunities with the added bonus of colorful foliage. The creek's ecosystem supports a diverse array of wildlife, particularly birds, making it an excellent destination for nature enthusiasts and birdwatchers. Paddlers may spot various species along the forested banks and in the surrounding farmlands.

Key landmarks include Sulphur Springs at river mile 23.0, the confluence with Tuscarora Creek, and several historic bridges. The Stone Bridge Access near Martinsburg offers a convenient put-in point with ample parking. Access points are scattered along the creek's course, with notable locations including Brucetown Bridge (VA), Route 45 (WV), Paynes Ford Road (WV), and Hoffman Road (WV). These access points are generally within easy reach of towns like Winchester, VA, and Martinsburg, WV.

The Opequon Creek holds historical significance as a long-standing border between Virginia and West Virginia, and its watershed has played a role in the agricultural development of the region. Safety considerations include being aware of private property boundaries, as some access points may cross or be near private land. Paddlers should also be prepared for occasional logjams or strainers, particularly after high water events.

For those interested in multi-day adventures, the full length of the Opequon Creek Water Trail spans 31.7 miles from near Hinton Road to Route 45, offering opportunities for extended trips with proper planning and camping arrangements. Overall, Opequon Creek provides a delightful paddling experience that showcases the natural beauty of the Shenandoah Valley region while offering accessible adventures for a range of skill levels.