The Guyandotte River is a 166-mile long tributary of the Ohio River that flows through southern West Virginia. Originating in Wyoming County, it travels northwest through Logan, Lincoln, and Cabell counties before joining the Ohio River at Huntington. Major tributaries include the Mud River, which joins near Barboursville.

The Guyandotte offers diverse paddling opportunities along its course. The upper reaches in Wyoming County feature an 8-mile stretch of Class I-III whitewater from Simon to R.D. Bailey Lake, popular among intermediate paddlers. As the river flows downstream, it transitions to mostly flatwater suitable for beginners and families. The 160-mile Guyandotte Water Trail provides a comprehensive paddling experience with 24 designated access points. Difficulty ranges from flatwater to Class III rapids, with most sections being Class I-II.

Spring typically offers the best water levels for whitewater, while summer is ideal for flatwater trips. The river passes through diverse Appalachian landscapes, from scenic mountain gorges to rolling farmland and urban areas. Wildlife viewing opportunities include deer, turkey, and various bird species. Black bear sightings are possible in more remote upper sections.

Key landmarks include R.D. Bailey Lake, a 630-acre impoundment offering additional paddling options, and the historic village of Guyandotte near the river's mouth. The river played a significant role in early settlement and transportation in the region.

Popular access points include Simon and Baileysville in Wyoming County, Man in Logan County, West Hamlin in Lincoln County, and Barboursville Park in Cabell County. Huntington provides urban paddling experiences near the confluence with the Ohio River.

Safety considerations include checking water levels, especially for whitewater sections, and being aware of potential strainers in wooded areas. Some sections may have limited cell phone coverage. Multi-day trips are possible along the Guyandotte Water Trail, with numerous camping options available. A full river descent from Wyoming County to Huntington would take approximately 7-10 days, offering an immersive journey through southern West Virginia's diverse landscapes and communities.