The Río Luján flows through the Delta del Paraná region in the northern Buenos Aires metropolitan area, passing through the towns of San Fernando and Tigre. It is part of one of the largest river delta systems in the world, a network of rivers, streams, and islands with notable biodiversity. The river sees considerable vessel traffic, which is an important safety consideration for paddlers sharing the water with larger boats.

A public boat ramp (Rampa de Acceso Público) is located next to the Club de Regatas Hispano Argentino and provides access to the river. In San Fernando, guided kayak tours operate from Boulevard de la Ribera 55, at the corner of Calle Colón and the Río Luján, offering an organized entry point for those unfamiliar with the area. Along the Tigre waterfront, the Paseo Victorica boulevard runs alongside the river, providing a recognizable landmark for paddlers navigating near the town center.

The Río Luján connects to the broader Delta waterway system, which includes calmer streams and wetlands suitable for bird watching, as well as access toward the Río de la Plata. Guided tours operating in the region recommend weekday paddling over weekends, as traffic and crowding on the water are lighter during the week.