Laguna Grande in Argentina is referenced in two distinct regional contexts, each offering a different paddling environment. In the province of Entre Ríos, it forms part of the Paraná - Victoria vía Paraná River and Laguna Grande Paddling Route. This route is a designated water trail where paddle sports including canoeing, kayaking, and stand-up paddleboarding are explicitly permitted. The route connects the Paraná River with Laguna Grande, suggesting it is a navigable water body suitable for multi-day or extended trips starting from the Victoria area.

In stark contrast, a separate Laguna Grande exists in the high-altitude, arid region of northern Argentina within the Antofagasta de la Sierra department of Catamarca province. This location is described as an important wetland. The primary visiting season for this area is between October and March, which likely corresponds to the most favorable conditions for any potential water-based activities. This Laguna Grande is situated in a dramatic alpine setting, with nearby routes leading to other features like Laguna Diamante, starting from a village at approximately 3,400 meters of elevation and reaching points above 4,200 meters. The extreme altitude and remote desert location define its character, presenting significant considerations for acclimatization, exposure, and self-sufficiency for any visitors.