Río Pipo flows through Tierra del Fuego National Park, located a short distance from Ushuaia in the Argentine province of Tierra del Fuego. The river runs through a valley that was historically used as a logging area by inmates from the Ushuaia penal colony, and the terminal station of the Fin del Mundo Train is situated near the river's area within the park.

The river's character includes at least one notable whitewater section known as the Cascada Río Pipo, where the water narrows and moves with force. A viewing platform overlooks this cascade, and the surrounding landscape features mountains rising prominently above the river corridor, with forested sections closer to the cascade. The overall setting is scenic, with the mountains providing a dramatic backdrop along the river's course.

Access to the Río Pipo area is via a dirt road branching off Ruta 3 inside the national park. A free campsite is available at Río Pipo within the park, with chemical toilets available from November through April, though there is no running water or other facilities. The campsite is included in the park entry fee. Entry to the park itself is free between May 1 and September 30, while a fee applies from October through the end of February.

Tierra del Fuego National Park permits canoeing and kayaking as activities, with rivers, lakes, and lagoons available for paddling within the park. Paddlers should be aware that the park has designated regulations and that any paddling activity falls under the park's general visitor rules. Given the sub-Antarctic location of Ushuaia and the park, water temperatures are cold year-round, and weather conditions in this region can be variable and demanding at any time of year.