The Indian River Lagoon is a 156-mile-long coastal estuary paralleling Florida's Atlantic coast from the Jupiter Inlet to the Ponce de León Inlet. This extensive, biodiverse water body is characterized by its connection to the Intracoastal Waterway and is studded with over 150 man-made spoil islands, many of which are accessible for landing, picnicking, and even primitive camping with no fee or reservation required. Paddlers should be aware this is a saltwater lagoon with tidal influence; one trip report noted a slow outgoing tide and the importance of timing launches with slack or favorable conditions. The lagoon's long, narrow shape and open stretches mean wind exposure and fetch can be significant, requiring paddlers to monitor conditions. Motorized boat traffic is present, particularly near the maintained channel and popular spoil islands.

Numerous public access points exist along its length, including specific launches like the North Causeway Bridge Park boat ramp in Fort Pierce, which has a dedicated canoe/kayak launch and nearby rentals. Other noted access points with facilities include the Wabasso causeway, which has a boat ramp, kayak launch, and restrooms. A key feature for trip planning is the network of spoil islands, most concentrated between Fort Pierce and Melbourne, which serve as destinations for day trips or overnight camping. Islands vary, with some having picnic tables and fire rings, while others are designated conservation islands where landing is prohibited to protect nesting birds. Camping is a primitive experience; you must pack in all supplies, including a portable toilet system, and pack out all waste.

Wildlife sightings are a major draw, with common encounters including bottlenose dolphins, manatees (especially in warmer periods), sea turtles, and a wide variety of wading birds like herons, egrets, and ospreys. The water clarity is noted to support clear kayak tours. Hazards for paddlers include sharp oyster shells, requiring closed-toe shoes, and potential encounters with alligators in tributary creeks. There is no alcohol allowed on vessels, and operating under the influence is illegal. The overall paddling experience offers a sense of escape into a natural, though not remote, environment with easy access to island exploration directly from urban centers.