Arroyo Soberbio, also known as Arroyo Guaramboca, is a 133.1-kilometer waterway in the province of Misiones, Argentina. It originates in the sierra de Misiones near the town of Capitán Antonio Morales in Departamento Guaraní, flowing southward until it empties into the río Uruguay near the city of El Soberbio. The arroyo drains a watershed of approximately 1,085 square kilometers, with its principal tributary being the arroyo Guaranaiba.

The upper portion of the watershed falls within the Reserva de la Biosfera Yabotí, a protected area of roughly 250,000 hectares, placing the arroyo within the selva paranaense ecosystem. Paddling the arroyo means traveling through dense jungle, and wildlife encounters are a regular feature of the experience. Marsh birds are commonly observed along the banks, kingfishers appear regularly, and howler monkeys can be heard from the surrounding forest canopy.

Kayaking is an established activity on the arroyo. Equipment rental, including kayaks and piraguas (dugout-style canoes), is available in El Soberbio at Puerto do Mario. The piragua is prized for its stability, making it suitable for fishing or photography on the water. The town of El Soberbio serves as the practical base for paddling the arroyo, and a range of accommodation options including hotels, cabins, camping, and lodges are available there, along with food services.

The arroyo's mouth near El Soberbio also provides access to the broader río Uruguay, which forms the natural border between Argentina and Brazil in this area. Paddlers based in El Soberbio can combine time on the arroyo with excursions on the río Uruguay, from which the Saltos del Moconá — described as the longest waterfall in the world — can be accessed by boat.