Oxley Creek is a tributary of the Brisbane River located in suburban Brisbane, Queensland, Australia. At 70 kilometres in length, it is Brisbane's longest creek and notably the only sand-based creek in the city. Its catchment covers approximately 260 square kilometres, rising in the hills of Undullah in Logan City and flowing through the western parts of Logan City before entering the City of Brisbane.

The lower reaches of the creek, passing through the suburbs of Oxley, Corinda, and Tennyson, contain the Oxley Creek Canoe Trail. This section is tidal, with the tidal influence extending upstream as far as the Ipswich Motorway crossing. Paddlers should factor tidal conditions into their planning, as water depth and current direction will vary accordingly. Up to Ed Kuepper (Lawson Street) Park, the creek is reported to be deep enough to paddle on any tide with minimal obstacles. There are multiple put-in points along this stretch.

A popular paddling route involves launching from the Brisbane River and turning into Oxley Creek, continuing down to the Secret Forest area and returning. The creek is bordered along its lower reaches by houses, parks, a driving range, and sports fields. The creek is crossed by the Logan Motorway and the Ipswich Motorway, and the surrounding winding areas are prone to flooding, particularly when there is overflow on the Rocklea flood plains from the tributary Stable Swamp Creek — a consideration for paddlers planning trips during or after heavy rainfall.

Water quality in the lower reaches is noted as heavily polluted, which is a relevant consideration for paddlers who may come into contact with the water. The broader Oxley Creek corridor is the subject of an ongoing transformation project aimed at developing it into a recreational and green space asset, with a 20-kilometre greenway trail planned along the creek linking the Brisbane River at Tennyson to bushlands at Larapinta.

Oxley Creek Common, located approximately 8 kilometres from Brisbane's CBD, is recognised as a significant birdwatching location and sits within the creek corridor, offering natural interest for paddlers passing through the area. The creek carries historical significance as the site where explorer John Oxley first surveyed it in December 1823, originally naming it Canoe Creek.