Upware Marina sits on the River Cam in the Cambridgeshire Fens, positioned near the confluence where Burwell Lode — fed by Reach Lode and Wicken Lode — joins the Cam roughly three miles upstream of Pope's Corner and the River Great Ouse.

It appears in the river's navigation sequence between Dimmock's Cot Bridge and Reach Lode. The marina offers moorings and a boat brokerage service, and is accessible by road from the A10 with onward connections to the M11, A14, and A1.

Its location provides boaters with access to the broader Fenland waterway network, including the Middle Levels and the River Nene beyond.

Wicken Fen National Nature Reserve and its windmill are within walking distance, making the site a useful base for exploring the area's protected wetland and wildlife habitats.