The River Nene (pronounced either "Nen" or "Nin" depending on the region) is a large river in the centre-east of England, measuring approximately 100 miles from source to sea, making it the 10th longest river in the UK. Rising in Northamptonshire, it flows north-east to the Wash at Lincolnshire. The navigable section runs from the Northampton Arm of the Grand Union Canal at Cotton End, Northampton, all the way to Bevis Hall near Wisbech St. Mary in Cambridgeshire, offering the possibility of a substantial multi-day paddling journey.

The river is generally described as calm and gentle, with a slow current — underwater weed tendrils are noted as often the only visible indicator of flow. This character makes it well suited to novice paddlers and those seeking a relaxed experience, though a reasonable level of fitness is helpful, particularly for portaging at locks. Locks appear at intervals along the river and require physical effort to move craft around; they are often picturesque spots for a break or picnic.

A popular day trip runs the 8.5 miles between Thrapston's Nine Arches Bridge and Oundle, passing through the Nene Valley with its flood plains, pools, and riverside willows and ash trees. The village of Wadenhoe, roughly halfway along this stretch, offers a riverside pub with grassy banks. Canoe hire operators such as Canoe2 are based in the area around Ditchford Lock in east Northamptonshire, providing equipment including paddles, buoyancy aids, watertight containers, and portage trolleys, along with safety briefings. The river is also accessible via Rushden Lakes.

Wildlife along the river includes swans, ducks, and fish. The landscape through the Nene Valley features meanders, willows, and open countryside typical of rural Northamptonshire.

At Northampton, the river feeds the Nene White Water Centre, an artificial white water course used for practice, rafting, and slalom competitions. Further downstream, the river connects with the Middle Level Navigations in the Fens of Cambridgeshire, a network of 99 miles of navigable drains linking the Nene to the River Great Ouse.

A waterways licence is required to paddle the River Nene. British Canoeing membership includes a waterways licence covering the river from below Northampton. The Environment Agency administers the navigation and sets registration fees for craft using the waterway.