Lake Memphremagog is a large lake straddling the Vermont-Quebec border, with its southern portion in Vermont's Northeast Kingdom. The lake's South Bay, a shallow appendage surrounded by low hills, offers protected paddling when north winds make the main lake challenging. South Bay is known for exceptional birding and wildlife viewing opportunities, including herons, kingfishers, and beavers.

Access points include the Vermont Fish and Wildlife South Arm Access Area at 619 Coventry Street in Newport, and a second access on Glen Road for the Barton River. The Black and Barton Rivers feed into South Bay, offering side trips through the South Bay Wildlife Management Area. The entrance to the Black River can be difficult to spot among the tall grasses.

For longer trips, Eagle Point provides an isolated primitive campsite on the eastern side of Lake Memphremagog, accessible only by water. Paddlers can launch from Johns River Ramp for a two-mile paddle to this site, which offers tent platforms and a privy but prohibits campfires.

Lake Memphremagog can experience harsh weather and rough water, with winds and waves becoming dangerous quickly. Paddlers should check weather forecasts before setting out. The lake crosses the international border, requiring paddlers to register at waterfront customs when entering Quebec or the US. All boats must display an aquatic nuisance inspection sticker on the Canadian side of the lake.

The town of Newport, located on the main lake, provides amenities including lodging, restaurants, grocery stores, and outfitters. The Northeast Kingdom Tasting Center and Kingdom Brewing offer local food and drink options for post-paddle refreshment.