The Río Carrilleufú flows through the Chubut province of Argentine Patagonia, connecting the eastern end of Lago Cholila to the northern end of Lago Rivadavia. The river is notably clear — widely regarded as among the clearest waterways in all of Patagonia — and is not particularly wide or large in scale. Its character makes it better suited to floating by boat or kayak than to wading.

A guided kayak excursion offered by local operators covers the full length of the river, launching at the headwaters on the eastern end of Lago Cholila and finishing at the river's mouth at the northern end of Lago Rivadavia. This route takes approximately six hours and is rated medium difficulty. Departures are typically in the morning, with a midday break on a broad sandy beach along the route. A minimum of four paddlers is generally required for organized trips.

The fishing season runs from November through May, which also represents the primary window for paddling activity on the river. The river is well known for rainbow, brown, and brook trout, and catch-and-release regulations apply across most sections. A valid fishing permit is required and can be obtained at local tourism offices and authorized agencies.

The river passes through a rich ecosystem that supports a variety of birdlife, including kingfishers, bandurrias, great grebes (huala), giant woodpeckers, and Andean condors in the higher surrounding terrain. The surrounding landscape is characteristic of Andean Patagonia, with the river accessible within a short drive from lodges in the area.

Facilities for paddlers are primarily provided through guided tour operators based in the Cholila area, who supply kayaks and basic paddling equipment. Paddlers planning independent trips should verify current permit requirements and access arrangements locally, as much of the river corridor passes through private or park-managed land.