The Río Epuyen flows through the Chubut province of Argentine Patagonia, in the area around the towns of Epuyén and Hoyo de Epuyén, near the foothills of the Andes. The river is accessible from Bariloche with roughly a two-hour drive, or from Esquel in approximately 50 minutes.

Kayak descents on the river include a route covering approximately 18.57 km to the river's mouth, and a longer route in the same general area running about 27.61 km with around 386 meters of cumulative elevation change, suggesting the river carries meaningful gradient in places. Paddlers have used sit-on-top kayaks for descents to the outflow point.

The Río Epuyen runs in close proximity to Lago Epuyén, with at least one campground — El Refugio del Lago — situated roughly 200 meters from the river. This campground offers basic amenities including hot-water facilities, a small store, and food service, making it a practical base for paddling trips in the area. The surrounding landscape is wooded, consistent with the Andean Patagonian forest environment typical of this part of Chubut.

Lago Epuyén prohibits motorized watercraft, which keeps boat traffic on the connected water system light and favors human-powered craft such as kayaks, canoes, SUPs, and rowboats. Whether this restriction extends formally to the river itself is unclear, but the absence of motorized traffic contributes to a quieter paddling environment overall.