The Estero River flows 6.4 miles through south Lee County, Florida, running east to west before emptying into Estero Bay, an inlet of the Gulf of Mexico. This unique waterway transitions from freshwater in its upper reaches to brackish and saltwater as it approaches the bay, creating distinct ecological zones that support diverse wildlife communities.

The river offers three primary paddling experiences centered around two main access points. Most paddlers launch from Koreshan State Park and head upstream for approximately 3 miles through the river's freshwater section, where dense mangroves give way to high banks lined with oak, palm, and cypress trees. This upstream journey begins as easy flatwater paddling but gradually becomes more technical as the river narrows and water levels drop. Light to moderate current varies with tides and recent rainfall, and natural obstacles eventually signal the turnaround point for a pleasant downstream return.

The official 9-mile Estero Bay and River Designated Paddling Trail connects Koreshan State Park to Lovers Key State Park, flowing downstream through brackish waters and mangrove forests before opening into Estero Bay. This route passes historic Mound Key Archaeological State Park and requires an open-water crossing of Estero Bay, making it suitable only for experienced paddlers comfortable with varying tides and wind conditions. Lovers Key State Park also offers a sheltered 5-mile canal trail within park boundaries, ideal for beginners and recreational paddling.

Wildlife viewing opportunities abound throughout the system, with frequent sightings of diverse waterbirds, manatees, alligators, otters, and turtles. Schools of fish are visible in the river's clearer upstream sections, while the mangrove areas provide habitat for numerous species protected by the Estero Bay Aquatic Preserve.

The river forms part of the Great Calusa Blueway, a 48.2-mile paddling system connecting various waterways throughout the region. Koreshan State Park provides historical context as the former site of a utopian religious community, while Mound Key Archaeological State Park preserves important Calusa Indian heritage sites.

Year-round paddling is possible in this subtropical climate, though summer months bring higher temperatures and afternoon thunderstorms. The upstream section from Koreshan provides excellent shade and shelter, while open-water portions require careful attention to weather conditions and tidal timing. Access fees apply at both state parks, with kayak rentals available through park concessionaires and local outfitters. The proximity to Fort Myers and Naples makes this an accessible destination, though weekend crowds are common at the popular Lovers Key location.