Gasparilla Sound is a coastal sound and aquatic preserve on Florida's Gulf Coast, forming a key part of the Charlotte Harbor estuary system. It separates the mainland from the barrier islands of Gasparilla Island to the west and Don Pedro Island to the east. The sound is characterized by expansive, open water with mangrove-lined shorelines, small keys, and connecting tidal creeks. For paddlers, the primary access points include the public launch site on Boca Grande at 19th Street, which has parking and restrooms, and the Coral Creek/CR775 Bridge paddle launch on the mainland near Placida. The sound is a designated segment of the Florida Circumnavigational Saltwater Paddling Trail, with a recommended multi-day route that includes camping on islands like Don Pedro and Dog Island before paddling along Gasparilla Island towards Cayo Costa.

Tidal currents are a significant factor for trip planning, and checking tide charts is considered crucial for accessing certain areas and managing paddling effort. The sound experiences heavy boat traffic, especially on weekends, and this is particularly intense in Boca Grande Pass from April through June during tarpon season. This pass, where the sound meets the Gulf of Mexico, is challenging due to strong currents, boat traffic, and potential breakers; it should only be crossed by experienced paddlers in optimum weather conditions. The open waters of the sound can also be exposed to wind, so paddlers should be prepared for changing conditions. Wildlife viewing is a major highlight, with frequent sightings of dolphins, manatees, and a wide variety of coastal birds including osprey and wading birds. The area features serene mangrove tunnels, especially along the eastern shore and in connecting creeks like Coral Creek, which offer more protected paddling. There are no trash cans at launch sites or in the preserve, so a strict pack-in, pack-out ethic is required to protect the pristine environment. Sun protection is essential due to the intense Florida sun with little shade on the open water.