Great Meadows National Wildlife Refuge offers nonmotorized boat access to the Concord River via a launch off Route 225 in Carlisle, as well as access to the Sudbury River from the Weir Hill Trail launch at the Sudbury Unit.

All anglers must comply with Massachusetts state fishing regulations and licenses, with catch-and-release only rules applying. Note that an entrance fee is required to access the Concord Unit.