Depot Slough is a tidal slough and tributary of the Yaquina River, located near Toledo, Oregon. It is a sheltered, inland waterway historically important for local industry. The primary access for paddlers is via the public boat launch on South Bay Road, managed by the Port of Toledo. The Port has also developed waterfront amenities including a viewing platform over the slough near its First Street office and a boardwalk along the riverfront. As a tidal feature connected to Yaquina Bay, paddlers must plan for tidal currents. The slough has been periodically dredged, though typically to depths sufficient for barges, indicating a generally shallow environment that can be affected by siltation. The overall paddling experience is characterized by its connection to Toledo's working waterfront and industrial history, offering a view of the area's heritage rather than a wilderness setting. The waterway provides access to the broader Yaquina River, where paddling and bird watching are noted activities. The Port of Toledo's short-term tie-up docks, a pumpout, and a dump station are reported as being open for boater use. Parks and viewing areas along the slough are for day use only and are closed from dusk to dawn. Given its location several miles inland from Newport, the slough benefits from warmer summer temperatures and protection from direct ocean winds, though paddlers should remain aware of wind and weather conditions on the wider river.