Calibogue Sound is a wide ocean channel and sound located on the western side of Hilton Head Island, South Carolina, forming part of the Intracoastal Waterway. It separates Hilton Head from Daufuskie Island to the west. This is an open, saltwater environment with significant exposure, recommended for experienced paddlers only due to its conditions. The average tidal swing is 6 to 8 feet, creating strong tidal currents that require careful planning; paddlers should consult a tidal chart and consider paddling against the current on the outbound leg to return with it. The open fetch means wind conditions can develop quickly, creating choppy water, especially when combined with boat traffic. Staying closer to shore provides smoother water. Major motorized boat traffic uses the deeper channels, but paddlers must remain vigilant, particularly when crossing these channels.

Primary launch points for accessing the sound are located within the Sea Pines area on Hilton Head's southern tip. The most prominent access is at Harbour Town Marina, next to the Harbour Town Lighthouse, where commercial tour operators like H2O Sports are based. This launch provides direct entry to the sound and nearby marshes. Other public boat landings with access to Calibogue Sound include the Cross Island Boat Landing on Helmsman Way, which connects via Broad Creek, and the Buckingham and Alljoy landings on the Bluffton mainland. The Alljoy landing is noted for having a long fetch and can be rough, with a drop-off at low tide and very limited parking.

The paddling experience is defined by expansive water views, active marine life, and significant human activity. The iconic red-and-white-striped Harbour Town Lighthouse is a major landmark visible from the water. Wildlife sightings are a key attraction, with frequent bottlenose dolphins, along with potential sightings of manatees, sea turtles, various herons, egrets, bald eagles, and otters. The surrounding salt marshes are accessible at high tide. For advanced paddlers with proper safety gear and tide awareness, a challenging open-water crossing to Daufuskie Island is a notable day trip. The best seasons for paddling are spring and summer, and mornings typically offer calmer conditions before afternoon winds pick up.